ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .

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Antibacterial activity of adhatoda vasica leaf extract

Accumulation of vasicine and vasicinone in tissue cultures of Adhatoda vasica and evaluation of the free radical-scavenging activities of the various crude extracts.

Please review our privacy policy. Materials and Methods 2. International Journal of Crude Drug Research. Every actkvity, at leastpeople die worldwide from cancer related to their workplace [ 3 ].

Fasica mobile phases A and B were used at flow rate of 1. Journal of Natural Products. Vasicine acetate showed moderate antibacterial activity compared to Vasicine. Vasicine hydrochloride, a new drug for interruption of pregnancy.

All melting point values are uncorrected and taken by open capillary method on a heating block Instrument. The estimation of Vasicine acetate content in the extract was performed using linear regression analysis. Council of Scientific and Antimiceobial Research; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Antibacterial Activity of Leaf Extracts of Adhatoda vasica – MAHE Digital Repository

Minimum Inhibitory Concentration MIC Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ].

Table 4 Cytotoxic effect of Vasicine acetate against A lung adenocarcinoma cancer cell line.

International Journal of Green Pharmacy. Vasicine acetate showed antimycobacterial activity [ 15 ]. In the present communication we report the antimicrobial, antioxidant, and anticancer effects of Vasicine acetate acetylated from Vasicine obtained from A.

Preliminary phytochemical and antibacterial screening of crude extract of the leaf of Adhatoda vasica. Results and Discussion The ethanol extract of A.

Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ]. Open in a separate window. Journal of Natural Product and Plant Resources. Separation was carried out at room temperature. Sankar2 and K. The mobile phase was filtered through a 0. HPLC chromatograms of the ethanol extract of the leaves of Adhatoda vasica.

Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness.

Vasicine acetate showed minimum inhibitory concentration values adhatofa bacteria; they were M. Antimicrobial and antimycobacterial activities of methyl caffeate isolated from Solanum torvum Swartz.

Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. The spot turned orange red on spraying with Dragendorff’s reagent. The crude extract of A.


It was studied for antimicrobial, antioxidant, and anticancer activities. Acanthaceae is used in the indigenous system of medicine in India.

Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

The structure of the isolated compound Vasicine and Vasicine acetate Figure 1. UV-Visible spectra were taken in methanol on Thermo Fisher instrument. The required concentrations, Negative control was prepared using respective solvents.

The column was eluted with chloroform and chloroform: Journal of Obstetrics and Gynaecology of India. Medicinal plants are important sources of practical drugs for people throughout the year.

Cytotoxicity of each sample was expressed as IC 50 value. The emergence of drug-resistant pathogens and the increase in diseases affecting the immune system have greatly intensified the need to investigate new bioactive metabolites for potential pharmaceutical and industrial applications [ 12 ].

The physical and spectroscopic data were compared with those reported in the literature [ 15 ]. Further elution of the column with chloroform: Natural products still remain the most important source for discovery of new axhatoda potential drug molecules.

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