Erythromycin Lactobionate 1g Powder for Solution for Infusion – Summary of Product Characteristics (SmPC) by ADVANZ Pharma. Erythromycin Lactobionate I.V. is a sterile presentation of erythromycin. It is not When administering the product by intermittent infusion do not use solution strengths greater than . includes any possible side effects not listed in this leaflet. Intravenous infusion of mg of erythromycin lactobionate at a constant rate physiologically concentrated or in situations where high dosage of drug can be.
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Read all information given to you. Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. Name of the medicinal product 2. There have been reports of infantile hypertrophic pyloric stenosis IHPS occurring in infants following erythromycin therapy.
Erythromycin has been reported to decrease the clearance of zopiclone and thus may increase the pharmacodynamic effects of this drug. Skin eruptions, pruritus, urticaria, exanthema, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme. Investigations Increased liver enzyme values. Medically reviewed on Sep 5, The induction decreases gradually during two weeks after discontinued treatment with CYP3A4 inducers.
The infusion should be completed within 8 hours of preparation to ensure potency. Erythromycin interferes with the fluorometric determination of urinary catecholamines. Since erythromycin may be used in the treatment of conditions in infants which are associated with significant mortality or morbidity such as pertussis or chlamydiathe benefit of erythromycin therapy needs to be weighed against the potential risk of developing IHPS.
If an allergic reaction occurs, the drug should be discontinued and appropriate therapy should be instituted. Rare reports of rhabdomyolysis have been reported in patients taking these drugs concomitantly. Call your doctor for medical advice about side effects.
Increases in serum concentrations paclage the following drugs metabolised by the cytochrome P system may occur: Appropriate monitoring should be undertaken and dosage should be adjusted as necessary.
Newborn infant birth to 1 month: There have been post-marketing reports of colchicine toxicity with concomitant use of erythromycin and colchicine. There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC. Marketing authorisation holder 8. Erythromycin is contraindicated in patients taking simvastatin, tolterodine, mizolastine, amisulpride, astemizole, terfenadine, domperidone, cisapride or pimozide.
Erythromycin Lactobionate – I.V. Information –
Solutions containing glucose may also be used but sodium bicarbonate must first be added as a buffer to ensure neutrality. Pseudomembranous colitis has been reported rarely in association with erythromycin therapy see section 4.
Bolus injection IV push is an unacceptable route of administration. Dosage Information lactobonate more detail. Following intravenous infusion, erythromycin is widely distributed throughout body tissues, including lung tissues. Sign Up Log In Cancel. Blood and lymphatic system disorders: GranulesErycSubscribe to receive email notifications whenever new articles are published. If you have questions about side effects, call your doctor.
Erythromycin Lactobionate 1g Powder for Solution for Infusion
There have been published reports suggesting when oral erythromycin is given concurrently with theophylline there is a significant decrease in erythromycin serum concentrations. Clostridium difficile-associated diarrhoea CDAD has been reported with use of nearly all antibacterial agents including erythromycin, and may range in severity from mild diarrhoea to fatal colitis.
Skin and soft tissue infections: Cholestatic hepatitis, jaundice, hepatic dysfunction, hepatomegaly, hepatic failure, hepatocellular hepatitis see section 4. The following have been reported: The stability of solutions of this medicine is adversely affected below pH 5.
For Continuous Infusion of 1 gram dose: These are not all of the side effects that may occur. Parents should lactobjonate informed to contact their physician if vomiting or packabe with feeding occurs. Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal sub-unit of susceptible microorganisms and suppresses protein synthesis. You may also report side effects at http: General disorders and administration site conditions: All drugs may cause side effects.
Use Erythromycin Lactobionate – I. Erythromycin significantly alters the metabolism of terfenadine, astemizole and pimozide when taken concomitantly. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
To email a medicine you must sign up and log in. As a result of this plasma levels of active steroid may decrease. Erythromycin is usually active against most strains of the following organisms both in vitro and in clinical infections: